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ImageCLEF 2018 Tuberculosis - MDR detection

Tuberculosis multi-drug-resistance detection based on CT image analysis



Important note:

The ImageCLEF Tuberculosis - MDR Detection challenge has officially ended and we would like to thank everybody for their participation. You can find the official results at http://imageclef.org/2018/tuberculosis .

Post-challenge submissions and the leaderboard will remain enabled for a few weeks so you will still be able to submit result files and have them continuously evaluated during a limited period. Please consider that in order to see the version of the leaderboard with the post-challenge submissions integrated, you have to turn on the switch Show post-challenge submission right below the leaderboard.

At the same time we’d like to encourage you to submit a CLEF Working notes paper until the end of May.

Please also note that participants registering from now on will not be automatically registered with CLEF anymore.

Note: ImageCLEF Tuberculosis 2018 is divided into 3 subtasks (challenges). This challenge is about MDR (multi-drug-resistance) Detection. For information on the TBT (tuberculosis type) Classfication challenge click here . For information on the Severity Scoring challenge click here . All of these challenges share the same dataset, so registering for one of these challenges will automatically give you access to the other ones.

Note: Do not forget to read the Rules section on this page


About 130 years after the discovery of Mycobacterium tuberculosis, the disease remains a persistent threat and a leading cause of death worldwide.

The greatest disaster that can happen to a patient with tuberculosis (TB) is that the organisms become resistant to two or more of the standard drugs. In contrast to drug sensitive (DS) tuberculosis, its multi-drug resistant (MDR) form is much more difficult and expensive to recover from. Thus, early detection of the drug resistance (DR) status is of great importance for effective treatment. The most commonly used methods of DR detection are either expensive or take too much time (up to several month). Therefore there is a need for quick and at the same time cheap methods of DR detection. One of the possible approaches for this task is based on Computed Tomography (CT) image analysis. Another challenging task is automatic detection of TB types (TBT) using CT volumes.

Differences compared to 2017: Scoring the severity of TB cases based on chest CT images is another task compared to both tuberculosis-related subtasks considered in 2017. There are no direct links between them. Note only that original CT image datasets used in 2017 and in 2018 may slightly overlap.

Challenge description

The goal of this challenge is to assess the probability of a TB patient having resistant form of tuberculosis based on the analysis of chest CT scan. More information will follow soon.


For this task, a dataset of 3D CT images is used along with a set of clinically relevant metadata. The dataset includes only HIV-negative patients with no relapses and having one of the two forms of tuberculosis: drug sensitive (DS) or multi-drug resistant (MDR). The MDR class includes patients with extensively drug-resistant (XDR) tuberculosis.

Num. Patients Train Test
DS 134 99
MDR 125 137
Total patients 259 236

We provide 3D CT images with slice size of 512*512 pixels and number of slices varying from about 50 to 400. All the CT images are stored in NIFTI file format with .nii.gz file extension (g-zipped .nii files). This file format stores raw voxel intensities in Hounsfield units (HU) as well the corresponding image metadata such as image dimensions, voxel size in physical units, slice thickness, etc. A freely-available tool called “VV” can be used for viewing image files. Currently, there are various tools available for reading and writing NIFTI files. Among them there are load_nii and save_nii functions for Matlab and Niftilib library for C, Java, Matlab and Python.

We also provide automatic extracted masks of the lungs. This material can be downloaded together with the patients CT images. The details of this segmentation can be found here . In case the participants use these masks in their experiments, please refer to the section “Citations” to find the appropriate citation for this lung segmentation technique.

Submission instructions

As soon as the submission is open, you will find a “Create Submission” button on this page (just next to the tabs)

Submit a plain text file named with the prefix MDR (e.g. MDRfree-text.txt) with the following format:

<Patient-ID>,<Probability of MDR>



Please use a score between 0 and 1 to indicate the probability of the patient having MDR.

You need to respect the following constraints:

  • Patient-IDs must be part of the predefined Patient-IDs
  • All patient-IDs must be present in the runfiles
  • Only use numbers between 0 and 1 for the score. Use the dot (.) as a decimal point (no commas accepted)


Information will be posted after the challenge ends.


The results will be evaluated using ROC-curves produced from the probabilities provided by participants.

The leaderboard will be visible from the 01.05.2018. However, the submission system will remain open few more days.


Note: In order to participate in this challenge you have to sign an End User Agreement (EUA). You will find more information on the ‘Dataset’ tab.

ImageCLEF lab is part of the Conference and Labs of the Evaluation Forum: CLEF 2018. CLEF 2018 consists of independent peer-reviewed workshops on a broad range of challenges in the fields of multilingual and multimodal information access evaluation, and a set of benchmarking activities carried in various labs designed to test different aspects of mono and cross-language Information retrieval systems. More details about the conference can be found here .

Submitting a working note with the full description of the methods used in each run is mandatory. Any run that could not be reproduced thanks to its description in the working notes might be removed from the official publication of the results. Working notes are published within CEUR-WS proceedings, resulting in an assignment of an individual DOI (URN) and an indexing by many bibliography systems including DBLP. According to the CEUR-WS policies, a light review of the working notes will be conducted by ImageCLEF organizing committee to ensure quality. As an illustration, ImageCLEF 2017 working notes (task overviews and participant working notes) can be found within CLEF 2017 CEUR-WS proceedings.


Participants of this challenge will automatically be registered at CLEF 2018. In order to be compliant with the CLEF registration requirements, please edit your profile by providing the following additional information:

  • First name

  • Last name

  • Affiliation

  • Address

  • City

  • Country

  • Regarding the username, please choose a name that represents your team.

This information will not be publicly visible and will be exclusively used to contact you and to send the registration data to CLEF, which is the main organizer of all CLEF labs

Participating as an individual (non affiliated) researcher

We welcome individual researchers, i.e. not affiliated to any institution, to participate. We kindly ask you to provide us with a motivation letter containing the following information:

  • the presentation of your most relevant research activities related to the task/tasks

  • your motivation for participating in the task/tasks and how you want to exploit the results

  • a list of the most relevant 5 publications (if applicable)

  • the link to your personal webpage

The motivation letter should be directly concatenated to the End User Agreement document or sent as a PDF file to bionescu at imag dot pub dot ro. The request will be analyzed by the ImageCLEF organizing committee. We reserve the right to refuse any applicants whose experience in the field is too narrow, and would therefore most likely prevent them from being able to finish the task/tasks.


ImageCLEF 2018 is an evaluation campaign that is being organized as part of the CLEF initiative labs. The campaign offers several research tasks that welcome participation from teams around the world. The results of the campaign appear in the working notes proceedings, published by CEUR Workshop Proceedings (CEUR-WS.org). Selected contributions among the participants, will be invited for publication in the following year in the Springer Lecture Notes in Computer Science (LNCS) together with the annual lab overviews.


Contact us

We strongly encourage you to use the public channels mentioned above for communications between the participants and the organizers. In extreme cases, if there are any queries or comments that you would like to make using a private communication channel, then you can send us an email at :

  • Sharada Prasanna Mohanty: sharada.mohanty@epfl.ch
  • Yashin Dicente Cid: yashin[DOT]dicente[AT]hevs[DOT]ch
  • Henning Müller: henning[DOT]mueller[AT]hevs[DOT]ch
  • Ivan Eggel: ivan[DOT]eggel[AT]hevs[DOT]ch

More information

You can find additional information on the challenge here: http://imageclef.org/2018/tuberculosis